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It may protect L02 cells from acetaminophen-induced damage by activating the Keap1-Nrf2 antioxidant defense mechanism

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f , Left, volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from KPK cells expressing a sgRNA targeting intergenic region or sgRNA targeting Slc33a1

Thus, we investigated whether the therapeutic efficacy of enzyme replacement with the enzyme rh-GLA could be recapitulated in the Fabry kidney organoid model